ASCE plus RHEOVA™ HA Filler

Product Details

ASCE plus RHEOVA™ is a premium cross-linked HA dermal filler line manufactured by ExoCoBio, a Korean biotech company known for its expertise in exosome and skin-science research. Built on a high-HA-content formulation with an advanced 8-step purification process, ASCE plus RHEOVA™ is engineered to deliver long-lasting viscoelasticity, superior gel shape retention, and enhanced safety through minimized residual BDDE — positioning it as a next-generation option for natural-looking, durable facial correction, backed by ExoCoBio's manufacturing and quality standards.

The line is available in three formulations — SOFT, MID, and STRONG — enabling practitioners to match product texture and duration to the treatment area and patient need.

Product Features

• Maintains viscoelastic properties immediately after injection
• Retains excellent viscoelasticity for several hours post-injection
• Demonstrates sustained shape retention and performance over time
• In-house degradation testing (5 units HAase) showed higher initial and 24-hour storage modulus (G′) values for the STRONG formulation versus multiple competitor products (Reference: in-house data)

• In a 2-hour in-house comparison, the STRONG formulation retained 79% of its original gel shape, versus 64% and 53% for two competing "ultra" formulations
• Positioned for longest duration and shape retention among comparators tested

• ASCE plus RHEOVA™ (STRONG): 24.36 mg/mL HA content — highest among compared products in-house (competitor range: 19.08–24.21 mg/mL)
• Higher HA content supports reduced BDDE use, helping further minimize residual BDDE

Product Line-Up

• Duration: 6–9 months
• Depth: Superficial to mid dermis
• Profile: The softest formulation in the line-up — fine wrinkle correction with subtle volumizing
• Indications: All facial wrinkles, lip lifting
• Cross-linking / Viscoelasticity: ○○○○● / ○○○●●

• Duration: 9–18 months
• Depth: Mid to deep dermis
• Profile: Balanced blend of large, medium, and small HA molecules — easy molding, natural-looking volume
• Indications: Nasolabial folds, forehead, marionette lines, face lifting
• Cross-linking / Viscoelasticity: ○○○●● / ○○●●●

• Duration: 12–24 months
• Depth: Mid to deep dermis / subcutaneous layer
• Profile: Firm formulation with the highest cross-linking and viscoelasticity in the line — designed for enhanced structural support, volume restoration, and facial contouring
• Indications: Temporary improvement of facial wrinkles (nasolabial folds)
• Cross-linking / Viscoelasticity: ○○●●● / ○●●●●

All formulations contain Lidocaine 0.3% for improved comfort during injection.