TheraFill ( Collagen Filler For Aesthetics )THERAFILL atelocollagen filler is a sterile and highly purified collagen filler,which is dissolved in phosphate-buffered solution to enable soft-tissueaugmentation by intradermal injection.TheraFill is biocollagen dermal filler manufactured by the Companys patenteddispersed in phosphate-buffered physiological saline, and filled in 1ml syringe,used for correction of wrinkles, nasolabial folds, scars and other soft tissue defects.The porcine based atelocollagen is much safer and no risky for BSE, unlike othercollagen injections which is made from bovine protein. Because it is structurallysimilar to human collagen, this product does not require skin testing.Collagen is a fibrous extracellular protein forming connective tissue of dermis.Collagen is inherently low in antigenicity and the most of its antigenicity areassumed to result from the telopeptide regions.TheraFill Atelocollagen Filler shows minimal antigen reaction because of the lack oftelopeptides by treatment with pepsin. It is made of porcine collagen (from piglets),not bovine collagen.Atelocollagen shows excellent properties for implantation in human body becauseporcine collagen is structurally similar to human collagen.AdvantagesImplanted TheraFill maintains collagen mass which replaced by normal surrounding tissue- Providing stable scaffolding structure- Inducing cell migration with enriched sites for adherent cells- Optimizing cell conduction into the scaffold- Advancing remodeling phase- Promoting fat cell viabilities- Ideal biocompatibilities- No risk for BSE- No skin test required- No antigenicity- Less side effects ( erythema, swelling )